The Nightshade was the secretary of the Mysterious Somebody during his reign over the PPC from 1992-1999 HST, having been promoted from her old job as a nurse after distinguishing herself during the insanity epidemic. During the Reorganisation she became dissatisfied with his rule and joined forces with the Orchid from the Mary Sue Factory in an effort to bring down her master. Her efforts were largely in vain due to the actions of Nyx Nightingale and the Sunflower Official; following the Mysterious Somebody's departure from the PPC, the Nightshade and the Orchid lived near the Factory, watching over his activities.
After the events of Crashing Down and the death of the Wisteria, the Nightshade became the Department Head of the Department of Operations.