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The macrovirus is a Trekverse organism that injects or sprays host bodies with virus-laced slime. Infected individuals grow lethargic, pass out, and churn more bugs out of their necks until they die from dehydration. Voyager's EMH developed a cure.

The macrovirus begins life microscopically inside a host body. By absorbing growth hormones from infected hosts, it grows bigger until it emerges from the host into the macroscopic world. Usually, it is visible and audible at this stage. More detail can be found here.

The aforementioned cure will stop the infection in a host body. An airborne macrovirus, sometimes called a bug, can be destroyed by an energy blast, killed by a breach in its outer shell (often caused by a pointy object or fast projectile), or by the cure. Of course, if it is too small for that, there is a problem.

The macrovirus has three observed instincts: to seek new hosts to infect, to consolidate existing hosts, and to struggle (slightly) if attacked.

The HQ Epidemic[]

Main article: 2008 Macrovirus Epidemic

In March 2008, the League of Mary Sue Factories sent two macrovirus-infected Mary Sues to HQ, resulting in an epidemic that led to the deaths of over one thousand agents, including Makes-Things.