Forbidden Substances

In addition to lethal poisons, there are a number of substances that Agents must never take or administer to anyone. Ever. Taking any of these is a Very Bad Idea and administering or disbursing them is liable to get you arrested by the DIA.

ADAM

 * Continuum: Bioshock
 * Reason: Both ADAM itself and Plasmids eat away at the mind of the user, leading to physical and mental addiction, not to mention insanity and the grotesque physical deformities that ensue.

Andris, Glitterstim, Glitteryll, or Yarrock spice

 * Continuum: Star Wars
 * Reason: Addictive. Abusers go mad. Glitteryll wipes memories, but not the selective way Bleeprin does.

Cocaine

 * AKA: Crack
 * Continua: Many
 * Reason: A major high, and one of the most addictive substances out there. Addicts often prefer it over food.

Crude

 * Continuum: Star Wars
 * Reason: Trivializes the user's inhibitions in his/her/its mind, so that he/she/it basically becomes an id.

Duncan's Dwarven Haggis

 * Continuum: World of Warcraft/The Chalice of Silvermoon
 * Reason: Definitely not the Scottish meat dish. Not fit for human consumption. Side effects include a diminished brain stem as well as a massive overbite and an increase in the size of a man's genitalia.

G-23 Paxilon Hydrochlorate

 * AKA: Pax
 * Continuum: Firefly
 * Reason: Causes death by apathy in 99.9% of the population, and insane aggression in the remainder (see Reavers).

Ixetal Cilona

 * AKA: Death sticks
 * Continuum: Star Wars
 * Reason: Very addictive, hallucinogenic, and each dose takes a successively longer amount of time off the user's life expectancy.

Melange

 * Continuum: Dune
 * Reason: So addictive that withdrawal is fatal, despite being able to extend life and grant prescient visions.

Methamphetamine

 * AKA: Meth
 * Continuum: Real World
 * Reason: Very addictive. Addicts become unable to enjoy anything else. Meth is implicated in some of the worst violent crimes; addicts lack the ability to care about anything but their desire to fund their habit, lack empathy, and become extremely unpredictable.

Nova

 * Continuum: Atlantyx
 * Reason: Hallucinogenic. When coupled with virtual reality (especially the novel's titular game, devised by a modern-day Cooger or Dark), causes severe addiction.

Sibosin

 * Continuum: Fates Worse Than Death
 * Reason: Removes need for sleep and dramatically increases psychic abilities at the expense of self-mutilation. Causes weird addictions to pain and suffering as well as the sleepless state.

Scrape, Slab, Slice, Slide, Sliver, Slunkie, and Slurp

 * Continuum: Discworld
 * Reason: Can severely reduce the functioning ability of trolls, making them catatonic and/or incredibly aggressive. Known to have little effect on humans.

Soma

 * Continuum: Brave New World
 * Reason: In less than a gram dose, it causes a temporary coma. Long-term abuse damages the respiratory system.

Soman

 * Continuum: Real World/PPC
 * Reason: A nerve agent that kills slowly and painfully in small doses. Dangerous even if a drop touches the skin. Brewed by Titus in an abandoned RC. An exception in that its relatively recent introduction to the PPC means that it can still be administered to Mary Sues.

Substance D

 * Continuum: A Scanner Darkly
 * Reason: Is addictive to the point where the addiction slowly kills you, hence its other name, "Slow Death". Causes vivid hallucinations, at times so vivid you could end up trying to kill yourself or mutilate yourself. Can also lead to extreme schizophrenia.

Vraxoin

 * AKA: Vrax, XYP
 * Continuum: Doctor Who
 * Reason: Causes total apathy. Withdrawal causes psychotic rages. According to The Doctor, it has caused worldwide chaos on several planets.

Wraithstone

 * Continuum: The Gentleman Bastard Sequence.
 * Reason: Wraithstone is a poison which affects the personality instead of the body. Anyone who inhales the smoke of burning Wraithstone is permanently rendered a mindless zombie. Even the notoriously cruel penal system of Camorr in its native continuum has banned its use on humans, though it's still used to "Gentle" pack animals to keep them easy to handle. Not to be used on Sues as it doesn't cause death.

X-1

 * Continuum: Star Wars
 * Reason Thinking gets muddled. Withdrawal is fatal.